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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
15/04/2021 |
Actualizado : |
15/04/2021 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
COSTA, D.; LÉVESQUE, S.; KUMAR, N.; FRESIA, P.; FERRÉS, I.; LAWLEY, T. D.; IRAOLA, G. |
Afiliación : |
DANIELA COSTA, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; Sección Genética Evolutiva, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay; SIMON LÉVESQUE, Laboratoire de Santé Publique du Québec, Quebec City, Canada; NITIN KUMAR, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; PABLO FRESIA, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; IGNACIO FERRÉS, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; TREVOR D. LAWLEY, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; GREGORIO IRAOLA, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Center for Integrative Biology, Universidad Mayor, Santiago de Chile, Chile. |
Título : |
Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts. |
Fecha de publicación : |
2021 |
Fuente / Imprenta : |
Scientific Reports, 2021, Volume 11, Issue 1, Article number 3431. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-021-82993-9 |
ISSN : |
2045-2322 |
DOI : |
10.1038/s41598-021-82993-9 |
Idioma : |
Inglés |
Notas : |
Article history: Received 12 February 2018; Accepted 24 January 2021; Published 09 February 2021. |
Contenido : |
ABSTRACT.
Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the underlying mechanism driving its diversification. Concordantly, both subspecies present distinct patterns of gene families involved in genome plasticity and DNA repair like CRISPR-associated proteins and restriction-modification systems. Together, our results provide an overview of the genetic mechanisms shaping the genomes of C. hyointestinalis subspecies, contributing to understand the biology of Campylobacter species that are increasingly recognized as emerging pathogens.
© 2021, The Author(s). MenosABSTRACT.
Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the under... Presentar Todo |
Palabras claves : |
Computational biology and bioinformatics; Evolution; Microbiology. |
Asunto categoría : |
A50 Investigación agraria |
URL : |
https://www.nature.com/articles/s41598-021-82993-9.pdf
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Marc : |
LEADER 02962naa a2200265 a 4500 001 1061986 005 2021-04-15 008 2021 bl uuuu u00u1 u #d 022 $a2045-2322 024 7 $a10.1038/s41598-021-82993-9$2DOI 100 1 $aCOSTA, D. 245 $aPangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts.$h[electronic resource] 260 $c2021 500 $aArticle history: Received 12 February 2018; Accepted 24 January 2021; Published 09 February 2021. 520 $aABSTRACT. Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the underlying mechanism driving its diversification. Concordantly, both subspecies present distinct patterns of gene families involved in genome plasticity and DNA repair like CRISPR-associated proteins and restriction-modification systems. Together, our results provide an overview of the genetic mechanisms shaping the genomes of C. hyointestinalis subspecies, contributing to understand the biology of Campylobacter species that are increasingly recognized as emerging pathogens. © 2021, The Author(s). 653 $aComputational biology and bioinformatics 653 $aEvolution 653 $aMicrobiology 700 1 $aLÉVESQUE, S. 700 1 $aKUMAR, N. 700 1 $aFRESIA, P. 700 1 $aFERRÉS, I. 700 1 $aLAWLEY, T. D. 700 1 $aIRAOLA, G. 773 $tScientific Reports, 2021, Volume 11, Issue 1, Article number 3431. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-021-82993-9
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INIA Las Brujas (LB) |
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Biblioteca (s) : |
INIA Tacuarembó. |
Fecha actual : |
21/02/2014 |
Actualizado : |
25/06/2019 |
Tipo de producción científica : |
Actividades de Difusión |
Autor : |
INIA TACUAREMBÓ; JICA (JAPAN INTERNACIONAL COOPERATION AGENCY) |
Afiliación : |
ESTACIÓN EXPERIMENTAL DEL NORTE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Avances en mejoramiento genético de eucalyptus grandis. |
Complemento del título : |
SEMINARIO DE CLAUSURA, Tacuarembó, Uruguay, 6 de marzo, 2002. |
Fecha de publicación : |
2002 |
Fuente / Imprenta : |
Tacuarembó (Uruguay): INIA, JICA, 2002. |
Páginas : |
7 p. |
Serie : |
(INIA - JICA Aftercare Forestal 2000-2002) (INIA Serie Actividades de Difusión ; 280) |
Idioma : |
Español |
Contenido : |
INTRODUCCIÓN. Elbio Berretta. PRESENTACIÓN GENERAL DEL AFTERCARE FORESTAL INIA-flCA. Zohra Bennadji-yoshitaka Uetsuki. RESULTADOS EN PROPAGACIÓN VEGETATIVA DE Eucaryptus grandis. EVALUACIÓN DE CARACTERÍSTICAS DE LA MADERA EN Eucaryptlls grandis. ESTIMACIÓN DE PARÁMETROS GENÉTICOS EN LA SEGUNDA GENERACIÓN DE Euca/yptus grandis Y SU UTILIZACIÓN PAR EL MANEJO DE LA POBLACIÓN MOLTIPROPÓSITO. EVALUACIÓN TEMPRANA DE FUENTES DE SEMILLA COMERCIAL DE Eucalyptus grandis. AGRADECIMIENTOS. |
Palabras claves : |
FOREST AND FORESTRY. |
Thesagro : |
EUCALYPTUS GRANDIS; FITOMEJORAMIENTO; MEJORA GENETICA. |
Asunto categoría : |
K10 Producción forestal |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/12446/1/SAD280.pdf
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Marc : |
LEADER 01118nam a2200193 a 4500 001 1023099 005 2019-06-25 008 2002 bl uuuu u00u1 u #d 100 1 $aINIA TACUAREMBÓ 245 $aAvances en mejoramiento genético de eucalyptus grandis. 260 $aTacuarembó (Uruguay): INIA, JICA$c2002 300 $a7 p. 490 $a(INIA - JICA Aftercare Forestal 2000-2002) (INIA Serie Actividades de Difusión ; 280) 520 $aINTRODUCCIÓN. Elbio Berretta. PRESENTACIÓN GENERAL DEL AFTERCARE FORESTAL INIA-flCA. Zohra Bennadji-yoshitaka Uetsuki. RESULTADOS EN PROPAGACIÓN VEGETATIVA DE Eucaryptus grandis. EVALUACIÓN DE CARACTERÍSTICAS DE LA MADERA EN Eucaryptlls grandis. ESTIMACIÓN DE PARÁMETROS GENÉTICOS EN LA SEGUNDA GENERACIÓN DE Euca/yptus grandis Y SU UTILIZACIÓN PAR EL MANEJO DE LA POBLACIÓN MOLTIPROPÓSITO. EVALUACIÓN TEMPRANA DE FUENTES DE SEMILLA COMERCIAL DE Eucalyptus grandis. AGRADECIMIENTOS. 650 $aEUCALYPTUS GRANDIS 650 $aFITOMEJORAMIENTO 650 $aMEJORA GENETICA 653 $aFOREST AND FORESTRY 700 1 $aJICA (JAPAN INTERNACIONAL COOPERATION AGENCY)
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